Genetic inactivation of acrAB or inhibition of efflux induces expression of ramA
نویسندگان
چکیده
منابع مشابه
Genetic inactivation of acrAB or inhibition of efflux induces expression of ramA
OBJECTIVES The transcriptional activator RamA regulates production of the multidrug resistance efflux AcrAB-TolC system in several Enterobacteriaceae. This study investigated factors that lead to increased expression of ramA. METHODS In order to monitor changes in ramA expression, the promoter region of ramA was fused to a gfp gene encoding an unstable green fluorescence protein (GFP) on the ...
متن کاملRamA, which controls expression of the MDR efflux pump AcrAB-TolC, is regulated by the Lon protease
OBJECTIVES RamA regulates the AcrAB-TolC multidrug efflux system. Using Salmonella Typhimurium, we investigated the stability of RamA and its impact on antibiotic resistance. METHODS To detect RamA, we introduced ramA::3XFLAG::aph into plasmid pACYC184 and transformed this into Salmonella Typhimurium SL1344ramA::cat and lon::aph mutants. An N-terminus-deleted mutant [pACYC184ramA(Δ2-21)::3XFL...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2013
ISSN: 1460-2091,0305-7453
DOI: 10.1093/jac/dkt069